Phytosome - more bioavailable
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چکیده
For good bioavailability, natural products must have a good balance between hydrophilicity (for dissolving into the gastro-intestinal fluids) and lipophilicity (to cross lipidic biomembranes). Many phytoconstituents like glycosilated polyphenolics have good water solubility, but are, nevertheless, poorly absorbed[1] because of their large size, incompatible with a process of passive diffusion and/or their poor miscibility with oils and other lipids. As a result, the ability of flavonoids to cross the lipid-rich outer membrane of small intestine enterocytes is severely limited.[2]
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Pharma Science Monitor an International Journal of Pharmaceutical Sciences Phytosomes: Novel Approach for Delivering Herbal Extract with Improved Bioavailability
Plant-derived polyphenols are increasingly gaining attention as dietary supplements for their multidimensional role in homeostatic management of inflammation, to support detoxication, and for anticancer, weight loss, and many other benefits. Many plants extracts rich in flavonoids and polyphenolics have been extensively explored for their pro-homeostatic effects on genes, transcription factors,...
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A recently developed oral formulation in the form of coated tablets (Monoselect Camellia) (MonCam) containing highly bioavailable green tea extract (GreenSelect Phytosome) was tested in obese subjects (n=100) of both genders on a hypocaloric diet. Fifty subjects were assigned to the green tea extract plus hypocaloric diet, while the other 50 subjects followed the hypocaloric diet only. After 90...
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BACKGROUND Most subjects regain weight after weight loss due to compensatory adaptations finalized to maintain stable body energy stores. Green tea (GT) preparations, which help maintain energy expenditure while dieting could be a useful strategy to facilitate weight maintenance. The usefulness of GT preparations in weight maintenance has been poorly studied so far with conflicting results. Thi...
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متن کاملPhyto-phospholipid complex: A tabular update
Phytoconstituents have been used in medicine science since ancient times due to their various pharmacological actions. But most of them (like flavanoids, terpenoids) are low in lipid solubility and have large molecular size due to complex multiple ring structure, causing poor absorption and poor bioavailability via oral route. The phytosome system of drug delivery results in increased bioavaila...
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